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ID 112034
タイトル別表記
肝細胞癌患者における術前血清CEA値上昇は上皮間葉転換を介して予後不良と関連する
Elevated Preoperative Serum CEA Level Is with Hepatocellular Carcinoma with Poor Prognosis Through the Epithelial-Mesenchymal Transition
著者
吉川, 雅登 徳島大学大学院医科学教育部(医学専攻)
東島, 潤 The University of Tokushima KAKEN研究者をさがす
石川, 大地 The University of Tokushima
寺奥, 大貴 The University of Tokushima
髙田, 厚史 The University of Tokushima
良元, 俊昭 The University of Tokushima
キーワード
CEA
CEACAM
epithelial mesenchymal transition
hepatocellular carcinoma
資料タイプ
学位論文
抄録
Background: Serum carcinoembryonic antigen (CEA) is used as an indicator of tumor progression in a variety of carcinomas. A subset of patients with hepatocellular carcinoma (HCC) exhibit increased serum CEA level, but the significance of this is unclear. In this study, we investigated the prognosis of patients with HCC with increased serum CEA, and explored the correlations with expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and epithelial–mesenchymal transition (EMT) and tumor angiogenesis. Materials and Methods: One hundred and twenty-three patients with HCC who underwent radical resection were divided into two groups according to a cut-off value of 5.0 ng/ml for serum CEA: high (n=24) and normal (n=99) groups. We compared the clinicopathological factors with serum CEA levels and its correlations with CEACAM1 expression, EMT-related factors and microvessel density (MVD) of tumor tissues by immunohistochemistry. Results: In the high CEA group, the disease-free survival (DFS) rate was significantly worse than in the normal CEA group. Multivariate analysis revealed that a high CEA level was an independent factor predictive of recurrence. Furthermore, increased serum CEA levels were positively correlated with CEACAM1 expression. Moreover, CEACAM1 expression was positively correlated with expression of EMT-related factors and MVD of tumor tissues. Conclusion: Increased serum CEA level reflected CEACAM1 expression and was an independent factor predictive of recurrence in HCC through EMT and tumor angiogenesis.
掲載誌名
Anticancer Research
ISSN
02507005
17917530
cat書誌ID
AA10625860
AA12440673
出版者
International Institute of Anticancer Research
37
3
開始ページ
1169
終了ページ
1175
発行日
2017-03-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者MASATO YOSHIKAWAの学位論文として提出され, 学位審査・授与の対象となっている。
公開に関する許諾確認は著者・編集事務局間のメールによる。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3204号
学位記番号
甲医第1379号
学位授与年月日
2018-07-26
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院