ID 57238
著者
樋浦, 明夫 Department of Oral Anatomy, School of Dentistry, Tokushima University KAKEN研究者をさがす
資料タイプ
学術雑誌論文
抄録
At present,the occurrence of first modulation of pain transmission in the superficial dorsal horn, especially in the substantia gelatinosa (SG: lamina II),is firmly established. Nociceptive primary,afferent central terminals (C-terminal) arising from nonmyelinated C-fibers and myelinated Aδ- fibers terminate in the SG and make synaptic glomeruli,in which they are centrally situated and surrounded by a number of dendrites and a few axonal terminals. One of the structural characteristics of C-terminals is indented,sinuous,or scalloped electron-dense axoplasm full of round synaptic vesicles (CI-terminal), while an other is larger roundish, electron-lucent axoplasm with many large dense core vesicles and mitochondria (CII-terminal). They are FRAP-and SP-or CGRP-positive and show intense capsaicinsensitivity. lnhibitory interneurons containing GABA,glycine or opioids are exclusively present in the SG. They contact with C-terminals,forming synaptic glomeruli. However,the synaptic relationship between C-terminals and inhibitory interneurons is controversial,i.e.,the postsynaptic contacts of inhibitory interneurons to C-terminals is not accepted. However,from previous reports concerning these synaptic structures,the presynaptic relationship of C-fibers to the inhibitory interneurons seem to be more enhanced,although species differences might be present.
ISBN
8130801620
掲載誌名
Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems
cat書誌ID
BA84948988
出版者
Research Signpost
開始ページ
1
終了ページ
22
発行日
2007
EDB ID
フルテキストファイル
言語
eng
部局
歯学系