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ID 113737
タイトル別表記
Cortical thymic epithelial cells
著者
キーワード
thymus
cortex
cortical thymic epithelial cell
positive selection
thymic epithelial progenitor
資料タイプ
学術雑誌論文
抄録
The thymic cortex provides a microenvironment for the development and positive selection of immature T cells. Cortical thymic epithelial cells (cTECs), which structurally and functionally support the thymic cortical microenvironment, originate from endodermal epithelial progenitors that arise in the third pharyngeal pouch. Recent studies have revealed that thymic epithelial progenitors pass through a stage where the cells express cTEC-associated molecules prior to lineage separation into cTECs and medullary TECs (mTECs). Here we review the molecular signatures of cTECs and highlight the development and developmental potential of cTECs.
掲載誌名
Immunological Reviews
ISSN
1600065X
01052896
cat書誌ID
AA00670246
出版者
John Wiley & Sons
271
1
開始ページ
10
終了ページ
22
発行日
2016-04-18
権利情報
This is the peer-reviewed version of the following article: Ohigashi, I. , Kozai, M. and Takahama, Y. (2016), Development and developmental potential of cortical thymic epithelial cells. Immunol Rev, 271: 10-22, which has been published in final form at https://doi.org/10.1111/imr.12404. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
先端酵素学研究所