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ID 111989
著者
Kishida, Takumi Tokushima University
Akiyoshi, Kenji Tokushima University
Erdenedalai, Erdenebat Tokushima University
Enhetomuru, Anu Tokushima University
キーワード
Dibromoacetonitrile
Water disinfection
Nonprotein thiol
Intracellular Zn2+ level
Lymphocytes
資料タイプ
学術雑誌論文
抄録
The aim of this study was to investigate the effects of dibromoacetonitrile (DBAN), a by-product in water bacterial control, at sublethal concentrations on rat thymocytes, by using a cytometric technique with appropriate fluorescent dyes. By using this method, the possibility that DBAN induces cellular actions related to oxidative stress was assessed. DBAN reduced the content of cellular nonprotein thiols under Zn2+-free conditions. It elevated the intracellular level of Zn2+, being independent from external Zn2+. DBAN increased cell vulnerability to the cytotoxic action of hydrogen peroxide. These actions of DBAN were likely related to oxidative stress. DBAN is formed by the reaction of bromides and chlorinated oxidants during water disinfection. Hydrolysis of 2,2-dibromo-3-nitrilopropionamide, an antimicrobial used in hydraulic fracturing fluids for production of shale gas and oil, produces DBAN. Therefore, the concern regarding the levels of DBAN in industrial water systems is necessary to avoid the environmental risk to humans and wild mammals.
掲載誌名
Toxicology in Vitro
ISSN
08872333
cat書誌ID
AA10678594
AA11540107
出版者
Elsevier
51
開始ページ
145
終了ページ
149
発行日
2018-05-23
権利情報
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
理工学系
生物資源系