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ID 115181
著者
Miyazaki, Aiko Tokushima University
Kakiuchi, Naoya Tokushima University
Okamoto, Kazumasa Tokushima University
キーワード
Flow titration
flow ratiometry
high-throughput titration
nonaqueous titration
Japanese Pharmacopoeia drug
資料タイプ
学術雑誌論文
抄録
Throughput rate of flow ratiometric titration has further been enhanced by shortening the lag time from the confluence of solutions upstream to the sensing of signal downstream and by optimizing analytical parameters. Feedback-based upward and downward scans of titrand/titrant flow ratio were repeated in order to offset the effect of the lag time and thus to locate the equivalence point. Subsequent faster fixed triangular wave-controlled scans in narrower range further increased the throughput rate. Analytical parameters such as scan rate and scan range were optimized. Maximally, 46.9 titrations/min was realized with reasonable precision (RSD = 1.79%). Applicability of the method to the quantitation of the Japanese Pharmacopoeia drugs (furosemide, isoniazid and prochlorperazine maleate) was verified, where the latter two drugs were determined by nonaqueous titrations.
掲載誌名
Journal of Flow Injection Analysis
ISSN
0911775X
24337374
cat書誌ID
AA10962565
出版者
Japanese Association for Flow Injection Analysis
36
2
開始ページ
97
終了ページ
100
発行日
2019
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系