アクセス数 : ?
ダウンロード数 : ?
ID 83802
著者
高浜, 洋介 Division of Experimental Immunology, Institute for Genome Research, University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
T lymphocyte
thymocyte
thymus
gene therapy
retrovirus
immune tolerance
資料タイプ
学術雑誌論文
抄録
T lymphocytes are the cells that play an essential role in regulating immune responses. The thymus is the organ in which T lymphocytes are generated. Our laboratory has investigated molecular signals that determine cell fate during T lymphocyte development in the thymus. To this goal, we have devised a technique in which one may efficiently introduce foreign genes into immature T lymphocytes. The somatic gene-transfer into developing T lymphocytes are likely useful to restore various immunodeficiencies and to establish immune tolerance to any introduced genes. The genetically engineered immune tolerance may be applied to reduce allergies and autoimmune diseases, as well as to sustain gene therapies by allowing prolonged survival of therapeutic vectors.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
48
1-2
開始ページ
25
終了ページ
30
並び順
25
発行日
2001
備考
フルテキストファイル
言語
eng
部局
先端酵素学研究所