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ID 115970
タイトル別表記
リンパ節のPET/CTによるSUVmaxに重み付け係数を乗じてCECTの最大短径を加えた新しいcombined indexによる舌癌の臨床的N0症例の潜在的リンパ節転移の評価
Combined index to evaluate N0 neck
著者
金村, 亮 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧
Suzuki, Motoyuki Osaka International Cancer Institute|Osaka University
Otozai, Shinji Osaka International Cancer Institute
Yoshii, Tadashi Osaka International Cancer Institute
Okamoto, Hidehiko International University of Health and Welfare
Fujii, Takashi Tokushima University
キーワード
Tongue cancer
lymph node metastasis
clinical N0 neck
occult nodal metastasis
PET/CT
資料タイプ
学位論文
抄録
To predict occult nodal metastasis in clinical N0 patients with tongue cancer, we developed combined index (CI) : SUVmax of the largest lymph node in PET/CT by weighting coefficient plus its maximum minor axis (< 10 mm) in contrast-enhanced CT (CECT). In this retrospective study, 57 clinical N0 patients with tongue cancer, who underwent elective supraomohyoid neck dissection at cervical levels of I-III were enrolled. The cutoff value of SUVmax of 2.0 obtained using receiver operating characteristic (ROC) analysis predicted the postoperative positive cervical levels containing metastatic lymph nodes from clinical N0 cervical levels in tongue cancer patients with a sensitivity of 54.5% and a specificity of 78.2%. The cutoff value of CI with weighting coefficient of 1.5 obtained using ROC analysis was 9.8 at the maximum area under the curve of 0.750. The cutoff value of 9.8 predicted the postoperative positive cervical levels containing metastatic lymph nodes from clinical N0 cervical levels in tongue cancer patients with a sensitivity of 68.2% and a specificity of 81.5%. These findings suggest that CI of functional PET/CT and morphological CECT components might improve the diagnostic performance of occult nodal metastasis to select clinical N0 patients with tongue cancer preferable for elective neck dissection.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
68
1-2
開始ページ
154
終了ページ
158
並び順
154
発行日
2021-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Ryo Kanamuraの学位論文として提出され,学位審査・授与の対象となっている。
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3487号
学位記番号
甲医第1491号
学位授与年月日
2021-03-17
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系