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ID 114360
タイトル別表記
Loss of Heterozygosity in Thyroid Tumors
著者
Kubo, Katsuyuki The University of Tokushima
Yokogoshi, Yutaka The University of Tokushima
Tsuyuguchi, Masaru Tokushima Municipal Hospital
齋藤, 史郎 The University of Tokushima
キーワード
Thyroid tumor
Loss of heterozygosity
Chromosome 1
資料タイプ
学術雑誌論文
抄録
We analyzed 53 loci on 21 chromosomes other than chromosome 4 to detect possible loss of heterozygosity in 31 thyroid tumors using polymorphic DNA markers that detect allelic deletions at specific chromosomal loci. Loss of heterozygosity on chromosomes 1, 7 and 12 was detected in one follicular thyroid adenoma, and on chromosome 1 in two medullary thyroid carcinomas. However, no loss of heterozygosity was detected at any of the loci examined in papillary thyroid carcinomas. These results suggest that chromosomal loss detected in thyroid adenoma is one of the signals for risk of premalignant transformation, and that inactivation of unknown genes on chromosome 1p contributes to tumorigenesis of medullary thyroid carcinoma. Some genetic changes other than chromosomal losses may participate in the tumorigenesis of papillary thyroid carcinoma.
掲載誌名
Japanese Journal of Cancer Research
cat書誌ID
AA00690844
出版者
Japanese Cancer Association|John Wiley & Sons
82
10
開始ページ
1097
終了ページ
1103
発行日
1991-10
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系