直近一年間の累計
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ID 110500
タイトルヨミ
トウニョウビョウセイ ニューロパチー ニオケル ジクサク イオン チャンネル キノウ
タイトル別表記
Axonal dysfunction in diabetic neuropathy
著者
梶, 龍兒 徳島大学医学部附属病院難聴診療部(高次脳神経診療部) 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
diabetic neuropathy
sodium channel
potassium channel
threshold electrotonus
latent addition
資料タイプ
学術雑誌論文
抄録
Diabetic neuropathy is characterized by the early decrease in motor conduction velocities and loss of vibratory sense. Autonomic dysfuncion may also be present in the early stage. These clinical features are not explainted by demyelination or Wallerian degeneration. Threshold tracking techniques such as latent addition or threshold electrotonus have been developed to explore the function of the ion channels non-invasively. Decreased peak Na current was found in diabetic patients, and is correlated with the decreased in motor conduction velocities. In ward rectifiers, which counteract membrane hyperpolatization, were found deficient in diabetic patients and models. This may lead to frequency-dependent conduction block, thus accounting for the early loss of vibratory sense. These clinical tests of axonal function is expected to reveal physiological information which the conventional nerve conduction studies could not provide previously.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
57
4-5
開始ページ
117
終了ページ
124
並び順
117
発行日
2001-10-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系