ID 112399
著者
田嶋, 敦 Tokushima University|Kanazawa University KAKEN研究者をさがす
Yamamori, Hidenaga Osaka University
Yasuda, Yuka Osaka University
Fujimoto, Michiko Osaka University
Shimodera, Shinji Kochi Medical School
Nakazawa, Takanobu Osaka University
Kikuchi, Masataka Osaka University
Nakaya, Akihiro Osaka University
Hashimoto, Hitoshi Osaka University
Hashimoto, Ryota Osaka University
キーワード
schizophrenia
DNA methylation
clozapine
資料タイプ
学術雑誌論文
抄録
Clozapine is an atypical antipsychotic, that is established as the treatment of choice for treatment-resistant schizophrenia (SCZ). To date, no study investigating comprehensive DNA methylation changes in SCZ patients treated with chronic clozapine has been reported. The purpose of the present study is to reveal the effects of clozapine on DNA methylation in treatment-resistant SCZ. We conducted a genome-wide DNA methylation profiling in peripheral leukocytes (485,764 CpG dinucleotides) from treatment-resistant SCZ patients treated with clozapine (n = 21) in a longitudinal study. Significant changes in DNA methylation were observed at 29,134 sites after one year of treatment with clozapine, and these genes were enriched for “cell substrate adhesion” and “cell matrix adhesion” gene ontology (GO) terms. Furthermore, DNA methylation changes in the CREBBP (CREB binding protein) gene were significantly correlated with the clinical improvements. Our findings provide insights into the action of clozapine in treatment-resistant SCZ.
掲載誌名
International Journal of Molecular Sciences
ISSN
14220067
16616596
cat書誌ID
AA12038549
出版者
MDPI
18
3
開始ページ
632
発行日
2017-03-14
権利情報
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系