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ID 112166
著者
Inoue, Tomomi Tokushima University
Kinoshita, Maika Tokushima University
Oyama, Keisuke Sakai City Medical Center
亀村, 典生 Tokushima Bunri University KAKEN研究者をさがす
キーワード
Captan
Intracellular Ca2+
Intracellular Zn2+
Nonprotein thiols
Superoxide anions
Lymphocytes
資料タイプ
学術雑誌論文
抄録
Captan, a phthalimide fungicide, is considered to be relatively nontoxic to mammals. There is a possibility that captan affects membrane and cellular parameters of mammalian cells, resulting in adverse effects, because of high residue levels. To test the possibility, we examined the effects of captan on rat thymic lymphocytes using flow-cytometry with appropriate fluorescent probes. Treatment with 10 and 30 μM captan induced apoptotic and necrotic cell death. Before cell death occurred, captan elevated the intracellular concentrations of Ca2+ and Zn2+ and decreased the concentration of cellular thiol compounds. These captan-induced phenomena are shown to cause cell death and are similar to those caused by oxidative stress. Captan also elevated the cytotoxicity of hydrogen peroxide. Results indicate that 10 and 30 μM captan cause cytotoxic effects on mammalian cells. Despite no report on the significant environmental toxicity hazard of captan in humans, it may exhibit adverse effects, described above, on wild organisms.
掲載誌名
Environmental Toxicology and Pharmacology
ISSN
13826689
cat書誌ID
AA1107880X
AA11526671
出版者
Elsevier
63
開始ページ
78
終了ページ
83
発行日
2018-08-27
権利情報
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
生物資源系