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ID 115937
タイトル別表記
高血圧患者におけるアンジオテンシン II-レニンフィードバック機構に対するL/N型カルシウムチャネル拮抗薬の影響
著者
川端, 豊 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Kitani, Mitsuhiro Kagawa Prefectural Shirotori Hospital
Kawano, Kazuhiro Yoshinogawa Medical Center
竹谷, 善雄 Shikoku Medical Center for Children and Adults KAKEN研究者をさがす
キーワード
L-/N-type calcium channel blocker
renoprotective effect
suppressing renin-angiotensin system
the ratio of Angiotensin-(1–7)/Angiotensin II
資料タイプ
学位論文
抄録
Objectives. Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin system (RAS). In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing the RAS.
Methods. A total of 25 hypertensive patients receiving a RAS inhibitor were randomly assigned to a cilnidipine (n = 12) or amlodipine (n = 13) group. The effects of cilnidipine on proteinuria and angiotensin II–renin feedback were assessed.
Results. After 6 months of treatment, both systolic and diastolic blood pressures were significantly reduced to a similar extent in both groups. The urine albumin-to-creatinine ratio was significantly lower in the cilnidipine group (p < 0.05) than in the amlodipine group. Amlodipine increased plasma angiotensin I and angiotensin II levels (p < 0.05), whereas cilnidipine did not. Interestingly, the cilnidipine group had a higher ratio of angiotensin-(1–7) (Ang-(1–7)) to angiotensin II in plasma than the amlodipine group (p < 0.05).
Conclusions. The L-/N-type CCB cilnidipine, but not amlodipine, decreased urinary albumin excretion in hypertensive patients. Cilnidipine also increased the ratio of Ang-(1–7) to angiotensin II in plasma, which might be one factor underlying its beneficial effects.
掲載誌名
International Journal of Hypertension
ISSN
20900384
20900392
出版者
Hindawi
2020
開始ページ
6653851
発行日
2020-12-22
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yutaka Kawabataの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
Copyright © 2020 Yutaka Kawabata et al.
This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3478号
学位記番号
甲医第1480号
学位授与年月日
2021-02-25
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系