直近一年間の累計
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ID 117559
著者
中西, 信人 Tokushima University
Hara, Kanako Tokushima University
Matsuo, Masafumi Kobe Gakuin University
キーワード
titin
muscle
diaphragm
atrophy
physical dysfunction
biomarker
urine
post-intensive care syndrome
nutrition
rehabilitation
資料タイプ
学術雑誌論文
抄録
Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.
掲載誌名
Journal of Clinical Medicine
ISSN
20770383
出版者
MDPI
10
4
開始ページ
614
発行日
2021-02-06
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系