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ID 116455
タイトル別表記
β5t shapes CD8 T cells without negative selection
著者
Frantzeskakis, Melina National Institutes of Health
Jacques, Alison National Institutes of Health
牛尾, 綾 National Institutes of Health
Yamashita, Fusano University of Tokushima
Yin, Da National Institutes of Health
Cam, Margaret National Institutes of Health
Kelly, Michael C. National Institutes of Health
Awasthi, Parirokh National Institutes of Health
資料タイプ
学術雑誌論文
抄録
The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8+ T cells; however, how the thymoproteasome contributes to CD8+ T cell development is unclear. Here, we show that the thymoproteasome shapes the TCR repertoire directly in cortical thymocytes before migration to the thymic medulla. We further show that the thymoproteasome optimizes CD8+ T cell production independent of the thymic medulla; independent of additional antigen-presenting cells, including medullary thymic epithelial cells and dendritic cells; and independent of apoptosis-mediated negative selection. These results indicate that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of negative selection in the thymus.
掲載誌名
Journal of Experimental Medicine
ISSN
00221007
15409538
cat書誌ID
AA00697559
AA12119243
出版者
Rockefeller University Press
218
4
開始ページ
e20201904
発行日
2021-02-08
権利情報
This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所
歯学系