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ID 110928
タイトル別表記
心エコー図検査で計測した心外膜下脂肪厚は誘発試験中の症候性冠攣縮と関連する
著者
西尾, 進 徳島大学大学院医科学教育部(医学専攻)
Hirata, Yukina Tokushima University
島袋, 充生 Fukushima Medical University KAKEN研究者をさがす
キーワード
Echocardiography
Epicardial adipose tissue
Vasospasm in patients with angina
Anterior interventricular groove
資料タイプ
学位論文
抄録
Background: Epicardial adipose tissue (EAT) is the ectopic visceral fat surrounding the heart, which plays an important role in atherosclerosis of the coronary arteries via endothelial damage. Several studies have also suggested that vasospasmwith angina (VSA) causes endothelial dysfunction in the coronary arteries. The aimof this study was to evaluate the thickness of EAT in the anterior interventricular groove (EAT-AIG) using echocardiography in patients who had no obstructive coronary artery disease and were suspected of having VSA.

Methods: Sixty-five patients who underwent intracoronary acetylcholine provocation testing for clinical indications were prospectively enrolled. VSA was diagnosed by coronary artery stenosis increase of >90% and the presentation of chest pain with ischemic changes on electrocardiography.

Results: Subjects were divided into two groups, with and without significant coronary spasm (VSA group, 30 patients; non-VSA group, 35 patients), consistent with acetylcholine provocation testing. EAT-AIG thickness was significantly greater in the VSA group than in the non-VSA group (8.2±2.7 vs 6.1±2.5 mm, P = .002). By receiver operating characteristic analysis, EAT-AIG thickness had a high C statistic (area under the curve = 0.81, P < .001) after adjustment for conventional risk factors (smoking, diabetes mellitus, and dyslipidemia). EAT-AIG thickness had incremental diagnostic value over other conventional risk factors (area under the curve = 0.81 vs 0.64, P for comparison = .020).

Conclusions: EAT-AIG thickness, which is noninvasively and easily measured using transthoracic echocardiography, can be one of multiple clinical variables associated with VSA.
掲載誌名
Journal of the American Society of Echocardiography
ISSN
08947317
cat書誌ID
AA10709494
出版者
The American Society of Echocardiography|Elsevier
30
10
開始ページ
1021
終了ページ
1027.e1
発行日
2017-08-23
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Susumu Nishioの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3104号
学位記番号
甲医第1348号
学位授与年月日
2017-09-28
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系