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ID 111530
タイトル別表記
Parathyroid cells : structure or Ca2+ sensing receptor
著者
斎藤, 史郎 徳島大学
キーワード
Ca2+ sensing receptor
Parathyroid
G protein coupled receptor
Familial hypocalciuric hypercalcemia
Autosomal dominant hypocalcemia
資料タイプ
学術雑誌論文
抄録
Using expression in Xenopus oocytes, Brown et al. cloned a bovine parathyroid Ca2+ sensing receptor (BoPCaRl). The 1,085 amino acid membrane protein is included in a class of putative seven transmembrane spanning structures that activate the phosphoinositol pathway through G proteins. Receptor activation presumably elevates intracellular Ca2+ to inhibit secretion of PTH. BoPCaRl has a big extracellular domain at the amino terminus. BoPCaRl is most similar to the metabotropic glutamate receptor. BoPCaRl mRNA is found in cells that have well known Ca2+ sensing function. Inheritance of one inactive Ca2+ sensing receptor gene causes familial hypocalciuric hypercalcemia (FHH) and autosomal dominant hypocalcemia. Mutations in the extracellular domain and in a portion of the third intracellular loop domain decrease the receptor’s sensitivity, causing FHH. Extracellular domain mutations increase the receptor’s activity at low Ca2+ concentration to cause autosomal familial hypocalcemia.
掲載誌名
日本臨牀
ISSN
00471852
cat書誌ID
AN00198641
出版者
日本臨牀社
53
4
開始ページ
805
終了ページ
810
発行日
1995-04
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
歯学系