ID | 110124 |
タイトル別表記 | 食餌性リンは大腸炎モデル動物の病態を悪化させる
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著者 |
杉原, 康平
徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Nakao, Mari
Tokushima University
Abuduli, Maerjianghan
Tokushima University
伊美, 友紀子
Tokushima University
Oda, Naoko
Tokushima University
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キーワード | Dietary Pi
DSS-induced colitis
proinflammatory cytokine
NF-κB
ROS
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資料タイプ |
学位論文
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抄録 | The recent widespread consumption of Western diets and food additives worldwide is associated with excessive inorganic phosphate intake. However, researchers have known little about the impact of dietary phosphate intake on the development of inflammatory bowel disease to date. In this study, we investigated the effects of dietary phosphate on intestinal inflammation in experimental colitis. Sprague-Dawley rats were fed different phosphate diets (0.5%, 1.0% and 1.5% phosphate) with or without dextran sulfate sodium. For in vitro study, the effects of phosphate on proinflammatory cytokine induction and reactive oxygen species production in RAW264.7 macrophage were examined. Dietary phosphate exacerbated intestinal inflammation in experimental colitis in a dose-dependent manner, as assessed by the clinical disease activity score, colon length, and histology. Furthermore, the high phosphate diet increased myeloperoxidase activity and proinflammatory cytokine mRNA expression through the activation of nuclear factor κB in the inflamed colon. In addition, high phosphate loading in RAW264.7 cells directly enhanced reactive oxygen species production and proinflammatory cytokine gene expression. Our results demonstrated that the high phosphate diet exacerbated intestinal inflammation in experimental colitis. These findings have important therapeutic implications for inflammatory bowel disease patients.
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掲載誌名 |
Journal of Clinical Biochemistry and Nutrition
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ISSN | 18805086
09120009
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cat書誌ID | AA10710201
AA12091064
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出版者 | SOCIETY FOR FREE RADICAL RESEARCH JAPAN
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巻 | 61
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号 | 2
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開始ページ | 91
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終了ページ | 99
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発行日 | 2017-09-01
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備考 | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201705191027.pdf 論文本文:k3010_fulltext.pdf 著者の申請により要約(2017-05-19公開)に替えて論文全文を公開(2018-02-15) 本論文は, 著者Kohei Sugiharaの学位論文として提出され, 学位審査・授与の対象となっている。 |
権利情報 | © 2017 Society for Free Radical Research Japan
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3090号
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学位記番号 | 甲栄第242号
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学位授与年月日 | 2017-03-23
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学位名 |
博士(栄養学)
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学位授与機関 |
徳島大学
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部局 |
医学系
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