ID | 115937 |
タイトル別表記 | 高血圧患者におけるアンジオテンシン II-レニンフィードバック機構に対するL/N型カルシウムチャネル拮抗薬の影響
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著者 |
Kitani, Mitsuhiro
Kagawa Prefectural Shirotori Hospital
Kawano, Kazuhiro
Yoshinogawa Medical Center
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キーワード | L-/N-type calcium channel blocker
renoprotective effect
suppressing renin-angiotensin system
the ratio of Angiotensin-(1–7)/Angiotensin II
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資料タイプ |
学位論文
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抄録 | Objectives. Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin system (RAS). In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing the RAS.
Methods. A total of 25 hypertensive patients receiving a RAS inhibitor were randomly assigned to a cilnidipine (n = 12) or amlodipine (n = 13) group. The effects of cilnidipine on proteinuria and angiotensin II–renin feedback were assessed. Results. After 6 months of treatment, both systolic and diastolic blood pressures were significantly reduced to a similar extent in both groups. The urine albumin-to-creatinine ratio was significantly lower in the cilnidipine group (p < 0.05) than in the amlodipine group. Amlodipine increased plasma angiotensin I and angiotensin II levels (p < 0.05), whereas cilnidipine did not. Interestingly, the cilnidipine group had a higher ratio of angiotensin-(1–7) (Ang-(1–7)) to angiotensin II in plasma than the amlodipine group (p < 0.05). Conclusions. The L-/N-type CCB cilnidipine, but not amlodipine, decreased urinary albumin excretion in hypertensive patients. Cilnidipine also increased the ratio of Ang-(1–7) to angiotensin II in plasma, which might be one factor underlying its beneficial effects. |
掲載誌名 |
International Journal of Hypertension
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ISSN | 20900384
20900392
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出版者 | Hindawi
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巻 | 2020
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開始ページ | 6653851
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発行日 | 2020-12-22
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Yutaka Kawabataの学位論文として提出され,学位審査・授与の対象となっている。 |
権利情報 | Copyright © 2020 Yutaka Kawabata et al.
This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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出版社版DOI | |
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言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3478号
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学位記番号 | 甲医第1480号
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学位授与年月日 | 2021-02-25
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学位名 |
博士(医学)
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学位授与機関 |
徳島大学
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部局 |
病院
医学系
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