ID 101816
Title Transcription
カブ チョクチョウ ガン ノ ジュツゼン ホウシャセン カガク リョウホウ ニヨル アタラシイ チリョウ センリャク
Title Alternative
Preoperative chemoradiotherapy as a new strategy for lower advanced rectal cancer
Author
Ando, Tsutomu Department of Digestive and Pediatric Surgery
Nishioka, Masaki Department of Digestive and Pediatric Surgery
Yawata, Yuko Department of Surgery, Taoka Hospital
Terashima, Yoshiyasu Department of Digestive and Pediatric Surgery
Ikushima, Hitoshi Department of Radiology, Iustitute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tashiro, Seiki Department of Surgery, Shikoku-Chuo Central Hospital Tokushima University Educator and Researcher Directory
Keywords
preoperative chemoradiation
rectal cancer
5-Fluorouracil
Content Type
Journal Article
Description
Purpose : To report cases of advanced rectal cancer that showed significant responses after
administration of preoperative chemoradiation therapy.
Methods : 5-Fluorouracil(5-FU, 300mg//day)was administered by 24-hour continuous intravenous
infusion after cancers had been decreased in size by radiation(2Gy)administered
for 20 days preoperatively. All patients then underwent low anterior resection with lymph
node dissection(two cases had super-low anterior resection).
Results : Clinical stages of all patients were down-staged preoperatively. All of operations
resulted in a curative resection of the cancer cells macroscopically. In one, histological examination
revealed no residual cancer cells in the resected specimen(CR).
Conclusion : Preoperative chemoradiation therapy was demonstrated as a promising regimen
for patients with advanced lower rectal cancer, and should be considered to extend indications
for even laparoscopic operations for advanced rectal cancer; a therapy tailor made for advanced
rectal cancer.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
60
Issue
3-4
Start Page
99
End Page
100
Sort Key
99
Published Date
2004-08-25
Remark
FullText File
language
jpn
departments
University Hospital
Medical Sciences