ID 102835
Title Transcription
ダイモウ ゲンパツ キョダイ GIST 1セツジョレイ
Title Alternative
A case of Giant Gastrointestinal Stromal Tumor Primarily Occurred in the Greater Omentum
Author
Miyake, Hidenori Department of Surgery, Tokushima Municipal Hospital
Aoyama, Mariko Department of Surgery, Tokushima Municipal Hospital
Matsumoto, Noriko Department of Surgery, Tokushima Municipal Hospital
Kanemura, Hirofumi Department of Surgery, Tokushima Municipal Hospital
Ogata, Yorihiko Department of Surgery, Tokushima Municipal Hospital
Miyoshi, Takanori Department of Surgery, Tokushima Municipal Hospital
Hino, Naoki Department of Surgery, Tokushima Municipal Hospital
Yamasaki, Shinichi Department of Surgery, Tokushima Municipal Hospital
Sonaka, Yasuhide Department of Surgery, Tokushima Municipal Hospital
Tsuyuguchi, Masaru Department of Surgery, Tokushima Municipal Hospital
Kudo, Eiji Department of Pathology, Tokushima Municipal Hospital
Kiyoku, Hiroshi Department of Pathology, Tokushima Municipal Hospital
Keywords
GIST
omentum
operation
Content Type
Journal Article
Description
We report a case of giant gastrointestinal stromal tumor(GIST)primarily occurred in the greater omentum. A78-year-old woman was referred to our hospital because of a giant abdominal tumor. Contrast-enhanced abdominal computed tomography(CT)showed a giant tumor measuring 20×24×13cm in diameter in the abdominal cavity, consisting of heterogeneously enhanced solid and cystic lesions. Abdominal magnetic resonance imaging(MRI)after 3 weeks from the first medical examination showed the enlarged tumor measuring24×25×17cm in diameter, the intensity of the solid lesion was low on T1weighted image, heterogeneously enhanced on T2weighted image and high on diffusion weighted image. At surgery, we confirmed the giant tumor continued to the omentum, and pressured the stomach, pancreas, and colon. The resected specimen weighed 8,325g containing of5,640ml of red-brown fluid. Histological examination showed the tumor consisted of proliferated spindle cells in a fascicular pattern and polynesic hemorrhage and necrosis. Immunohistochemically, the tumor cells were positive for c-kit and CD34, and negative for S‐100 protein and desmin, indicating a GIST in the greater omentum. The mitotic figures were in a40/50 high power field. In genetic testing, the tumor cells had exon11mutation of c-kit gene. The woman started taking imatinib after operation and remains alive and recurrence-free.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
68
Issue
3-4
Start Page
139
End Page
146
Sort Key
139
Published Date
2012-08-25
Remark
FullText File
language
jpn
departments
University Hospital