ID 102837
Title Transcription
シンケイコン ショウガイ デ ハッショウシタ シンケイ サルコイドーシス ノ イチレイ
Title Alternative
A case of neurosarcoidosis with radiculopathy
Author
Yano, Hajime The Post-graduate Education Center, Tokushima University Hospital
Saijo, Atsuro Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kondo, Mayo Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital
Kawano, Hiroshi Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital Tokushima University Educator and Researcher Directory
Toyoda, Yuko Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kakiuchi, Souji Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital KAKEN Search Researchers
Kishi, Jun Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital KAKEN Search Researchers
Hanibuchi, Masaki Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital KAKEN Search Researchers
Furukawa, Takahiro Department of Neurology, Tokushima University Hospital Tokushima University Educator and Researcher Directory
Nishioka, Yasuhiko Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
neurosarcoidosis
radiculopathy
prednisolone
methotrexate
Content Type
Journal Article
Description
A52-year-old woman was referred to our hospital for further examination of thoracolumbar pain. As dysesthesia at Th4level was seen in neurological examination, thoracic radiculopathy or myelopathy was suspected. Blood examination showed elevated level of serum ACE and lysozyme. Lymphadenopathy was evident in bilateral hila and mediastina with marked FDG and Gallium accumulation in FDG-PET-CT and Gallium scintigraphy, respectively. The number of lymphocytes and the CD4/CD8ratio were increased in the BALF. Histological findings of specimens obtained from the lung and the skin lesion revealed noncaseating epithelioid granuloma, which yielded the diagnosis of sarcoidosis. The cerebrospinal fluid examinations showed elevated level of cell counts, proteins and β2-microglobulin. Taken together, she was diagnosed as neurosarcoidosis with thoracic radiculopathy. Her symptoms were improved with oral administration of prednisolone, but they were exacerbated when prednisolone dose was tapered to20mg/day. Combined therapy of methotrexate and prednisolone was initiated, thereafter her symptoms disappeared completely.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
68
Issue
3-4
Start Page
153
End Page
158
Sort Key
153
Published Date
2012-08-25
Remark
EDB ID
FullText File
language
jpn
departments
Medical Sciences
University Hospital