ID 103612
Author
Hiura, Akio Oral Histology, School of Dentistry, University of Tokushima KAKEN Search Researchers
Nakagawa, Hiroshi Pediatric Dentistry, Tokushima University Hospital, University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Capsaicin
Aoptosis
DNA ladder
Okadaic acid
Content Type
Journal Article
Description
The aim of this study was to examine whether the neonatal injection of capsaicin induces DNA ladder formation, as an indicator of apoptosis, in the rat trigeminal ganglion (TG). The DNA extracted from the TGs after treatment with capsaicin (50 mg/kg) at 2 days of age exhibited diffuse DNA fragmentation instead of “ladder formation”, as determined by agarose gel electrophoresis. In contrast, clear DNA ladder formation was induced in human osteosarcoma cells treated with okadaic acid (OA) at concentrations of 10 and 20 nM. These results suggest that capsaicin cannot induce apoptosis of TG neurons sufficient for detectable DNA ladder formation. Thus, it is conceivable that capsaicin mainly causes necrosis rather than apoptosis in rodent primary sensory neurons.
Journal Title
WebmedCentral TOXICOLOGY
ISSN
20461690
Publisher
WebmedCentral
Volume
3
Issue
9
Start Page
WMC003708
Published Date
2012-09-18
Remark
Article URL: http://www.webmedcentral.com/article_view/3708

This is an open-access article distributed under the terms of the Creative Commons Attribution License(CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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DOI (Published Version)
URL ( Publisher's Version )
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language
eng
TextVersion
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departments
University Hospital
Oral Sciences