ID 103613
Author
Hiura, Akio Oral Histology, School of Dentistry, University of Tokushima KAKEN Search Researchers
Nakagawa, Hiroshi Dentistry for Persons with Disability, Tokushima niversity Hospital, University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Glias
TRP channels
Inflammatory soup
Abnormal pain
Acute noxious heat pain
Content Type
Journal Article
Description
Nowadays, one cannot but recognize a key role of the peripheral and central glial cells for generation of clinical neuropathic pain. Many cytokines are released from glial cells, immune cells and nociceptive primary afferent central or peripheral terminals by injury, bacterial or viral infection, and envenomation by bee venom or scorpion. Released cytokines mutually affect by paracrine or autocrine manner among glias, immune cells and neurons, thereby produce and transmit the exaggerating pain information to the brain. Indeed, suppression of activated glia and immune cells by chemical agents or antibodies can relief abnormal pain caused by various experimental neuropathies. Thus, abnormal exaggerated pain cannot be explained without the role of glia and immune cells. Many investigators emphasized that therapeutic use of inactivating agents to glial and immune cells but not to neurons is available for alleviation of clinical pain. Thermo-TRP channels, TRPV1, TRPA1 and TRPM8 could not sense neuropathic pain by themselves without close interactions between glias, immune cells and TRP channels. The removal of persistent clinical pain will be rescued by treatment with inactivating chemicals to glias and immune cells. In addition, physiological noxious heat could be sensed by unknown sensor other than thermo-TRP channels, TRPV1, TRPA1 and TRPM8
Journal Title
WebmedCentral PAIN
ISSN
20461690
Publisher
WebmedCentral
Volume
3
Issue
9
Start Page
WMC003728
Published Date
2012-09-27
Remark
Article URL: http://www.webmedcentral.com/article_view/3728

This is an open-access article distributed under the terms of the Creative Commons Attribution
License(CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Oral Sciences