ID 106005
Author
Sakai, Tohru Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Shuto, Emi Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Taki, Tomoyo Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Imamura, Honami Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Kioka, Miku Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Nakamoto, Akiko Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Mizoguchi, Seiji Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Amano, Shouko Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Kawano, Yukari Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Nakamoto, Mariko Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tsutumi, Rie Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Hosaka, Toshio Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Keywords
cathepsin E
dendritic cells
MHC class II
NC/Nga mice
Content Type
Journal Article
Description
NC/Nga (NC) mice are an animal model for human atopic dermatitis. We found that induction of antigen (Ag)-specific T cell response is diminished in ovalbumin (OVA)- immunized NC mice. Ability of Ag presentation in NC mouse dendritic cells (DCs) was significantly weaker than that in BALB/c and DBA/2 mouse DCs. Expression levels of MHC class II molecules and cathepsin E in NC mouse DCs were significantly lower that those in BALB/c and DBA/2 mouse DCs. These results indicate that low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
59
Issue
1-2
Start Page
95
End Page
101
Sort Key
95
Published Date
2012-02
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences