ID 106018
Author
Sumitani, Satoru Center for Preventive Medicine, Nissay Hospital|Department of Medicine, Nissay Hospital
Morita, Shinya Department of Medicine, Nissay Hospital
Utsu, Yoshihiko Department of Medicine, Nissay Hospital
Mukai, Kosuke Department of Medicine, Nissay Hospital
Miki, Shunji Department of Medicine, Nissay Hospital
Sato, Bunzo Department of Medicine, Nissay Hospital
Nakamura, Hideji Center for Preventive Medicine, Nissay Hospital
Kasayama, Soji Department of Medicine, Nissay Hospital
Keywords
management
type 2 diabetes
metformin
lifestyle interventions
hypoglycemia
Content Type
Journal Article
Description
Although global guidelines recommend metformin and lifestyle interventions as an initial treatment in patients with newly diagnosed type 2 diabetes (T2DM), few reports exist about its effectiveness in Japanese patients. To examine its effectiveness, we performed a prospective observational study within a routine clinical setting. We provided metformin (≥1,500 mg/day) and lifestyle interventions to 23 patients with newly diagnosed T2DM (20 men and 3 women, mean age 53 years, mean body mass index [BMI] 25.7 kg/m2). After 16 weeks, HbA1c levels significantly decreased from 9.1±2.1% (mean±SD) to 6.6±0.8% (p<0.001). Thirteen patients (56.5%) achieved a target HbA1c<6.5%. We did not find a significant correlation between baseline BMI and the changes in HbA1c (ΔHbA1c) (r=-0.165, p=0.451). In contrast, we found a significant correlation between baseline fasting plasma glucose and ΔHbA1c (r=-0.755, p<0.001). Body weight decreased from 73.3±13.3 kg to 69.8±11.6 kg (p<0.001). Total cholesterol, low density lipoprotein-cholesterol, non-high density lipoprotein-cholesterol, and serum vitamin B-12 concentrations also significantly decreased. Adverse events included diarrhea (26.1%) and mild elevation of liver enzymes (8.7%). These results suggest that metformin and lifestyle interventions is effective and safe as an initial treatment in Japanese patients with newly diagnosed T2DM.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
59
Issue
1-2
Start Page
166
End Page
173
Sort Key
166
Published Date
2012-02
FullText File
language
eng
TextVersion
Publisher