ID 106020
Author
Shibata, Hirofumi Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Nishitani, Noriko Graduate School of Pharmaceutical Sciences, the University of Tokushima
Yaohara, Sayuri Graduate School of Pharmaceutical Sciences, the University of Tokushima
Arakaki, Naokatu Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Higuti, Tomihiko Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kawazoe, Kazuyoshi Department of Clinical Pharmacy, Institute of Health Biosciences, the University of Tokushima Graduate School|Division of Pharmacy, Tokushima University Hospital KAKEN Search Researchers
Minakuchi, Kazuo Department of Clinical Pharmacy, Institute of Health Biosciences, the University of Tokushima Graduate School|Division of Pharmacy, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
statin
bacterial translocation
MDCK
P. aeruginosa
Content Type
Journal Article
Description
Pseudomonas aeruginosa causes both invasive (bacteremic) and chronic noninvasive infections. An increase in intestinal epithelial permeability is a characteristic of severe sepsis. Alterations in the normal barrier function of the gut mucosa may result in the translocation of microbial cells and products. On the otherhand, it has been demonstrated that statin use is associated with a lower risk of mortality from bloodstream infections. Therefore, we investigated the ability of P. aeruginosa PAO1 to translocate across the Madin-Darby canine kidney (MDCK) cell monolayers in the presence and absence of simvastatin. The bacteria readily translocated across MDCK cell monolayers after 3 h of infection irrespective of the presence or absence of the drug in the medium. However, the bacteria were less able to penetrate the MDCK monolayers in the presence of simvastatin than in its absence. A gentamicin survival assay demonstrated that simvastatin did not affect the bacteria’s invasive behavior in the MDCK cells.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
59
Issue
1-2
Start Page
186
End Page
191
Sort Key
186
Published Date
2012-02
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences
Medical Sciences