ID | 106020 |
Author |
Shibata, Hirofumi
Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
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Nishitani, Noriko
Graduate School of Pharmaceutical Sciences, the University of Tokushima
Yaohara, Sayuri
Graduate School of Pharmaceutical Sciences, the University of Tokushima
Arakaki, Naokatu
Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
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Higuti, Tomihiko
Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
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Kawazoe, Kazuyoshi
Department of Clinical Pharmacy, Institute of Health Biosciences, the University of Tokushima Graduate School|Division of Pharmacy, Tokushima University Hospital
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Minakuchi, Kazuo
Department of Clinical Pharmacy, Institute of Health Biosciences, the University of Tokushima Graduate School|Division of Pharmacy, Tokushima University Hospital
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Keywords | statin
bacterial translocation
MDCK
P. aeruginosa
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Content Type |
Journal Article
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Description | Pseudomonas aeruginosa causes both invasive (bacteremic) and chronic noninvasive infections. An increase in intestinal epithelial permeability is a characteristic of severe sepsis. Alterations in the normal barrier function of the gut mucosa may result in the translocation of microbial cells and products. On the otherhand, it has been demonstrated that statin use is associated with a lower risk of mortality from bloodstream infections. Therefore, we investigated the ability of P. aeruginosa PAO1 to translocate across the Madin-Darby canine kidney (MDCK) cell monolayers in the presence and absence of simvastatin. The bacteria readily translocated across MDCK cell monolayers after 3 h of infection irrespective of the presence or absence of the drug in the medium. However, the bacteria were less able to penetrate the MDCK monolayers in the presence of simvastatin than in its absence. A gentamicin survival assay demonstrated that simvastatin did not affect the bacteria’s invasive behavior in the MDCK cells.
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Journal Title |
The journal of medical investigation : JMI
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ISSN | 13431420
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NCID | AA11166929
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Volume | 59
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Issue | 1-2
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Start Page | 186
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End Page | 191
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Sort Key | 186
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Published Date | 2012-02
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EDB ID | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Pharmaceutical Sciences
Medical Sciences
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