ID 106040
Author
Koga, Masafumi Department of Internal Medicine, Kawanishi City Hospital
Shimizu, Ikki Department of Diabetes, The Sakakibara Heart Institute of Okayama
Murai, Jun Department of Internal Medicine, Kinki Central Hospital
Saito, Hiroshi Department of Internal Medicine, Kinki Central Hospital
Kasayama, Soji Department of Medicine, Nissay Hospital
Kobayashi, Tetsuro The Third Department of Internal Medicine, University of Yamanashi School of Medicine
Imagawa, Akihisa Department of Metabolic Medicine, Osaka University Graduate School of Medicine
Hanafusa, Toshiaki Department of Internal Medicine (I), Osaka Medical College
the Members of the Japan Diabetes Society’s Committee of Research on Type 1 Diabetes Mellitus
Keywords
glycated albumin
HbA1c
fulminant type I diabetes mellitus
pregnancy
Content Type
Journal Article
Description
Fulminant type 1 diabetes mellitus (FT1DM) develops as a result of very rapid and almost complete destruction of pancreatic β cell. The most common form of type 1 diabetes mellitus with onset during pregnancy has been shown to be FT1DM at least in Japan. We previously reported that the ratio of glycated albumin (GA) to HbA1c (GA/HbA1c ratio) is elevated in FT1DM patients at the diagnosis. In the present study, we investigated whether the GA/HbA1c ratio is also elevated in FT1DM with onset during pregnancy (P-FT1DM). The study subjects consisted of 7 patients with P-FT1DM. Ten patients with untreated type 2 diabetes mellitus (T2DM) discovered during pregnancy (P-T2DM) and 9 non-pregnant women with untreated T2DM (NP-T2DM) were used as controls. All study patients satisfied HbA1c<8.7%, the diagnostic criteria for FT1DM. The GA/HbA1c ratio in the P-FT1DM patients at the diagnosis was significantly higher than that in the P-T2DM patients and the NP-T2DM patients. The GA/HbA1c ratio was ≥3.0 in all P-FT1DM patients, whereas it was <3.0 in 8 of 10 P-T2DM patients and all NP-T2DM patients. The GA/HbA1c ratio was also elevated in P-FT1DM patients at the diagnosis compared with T2DM with or without pregnancy.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
60
Issue
1-2
Start Page
41
End Page
45
Sort Key
41
Published Date
2013-02
FullText File
language
eng
TextVersion
Publisher