ID 106041
Author
Bando, Ryota Department of Clinical Support, the Tokushima University Hospital
Ikushima, Hitoshi Department of Radiation Therapy Technology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kawanaka, Takashi Department of Radiology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kudo, Takaharu Department of Oral Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sasaki, Motoharu Department of Clinical Support, the Tokushima University Hospital Tokushima University Educator and Researcher Directory
Tominaga, Masahide Department of Radiation Therapy Technology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kishi, Taro Department of Clinical Support, the Tokushima University Hospital
Furutani, Shunsuke Department of Radiology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kubo, Akiko Department of Radiology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tamura, Koichi Department of Otorhinolaryngology and Communicative Neuroscienece, Institute of Health Biosciences, the University of Tokushima Graduate School
Keywords
adaptive strategy
chemoradiation therapy
head and neck cancer
Content Type
Journal Article
Description
The treatment period over which radiation therapy is administered extends over several weeks. Since tumor shrinkage in response to radiation therapy and weight loss due to radiation-induced mucositis may impact on the dose distribution in both target and organ at risk in patients with head and neck cancer, the anatomical changes of tumor and neck volumes during this period should be taken into consideration. We investigated the anatomical changes that occurred in the target and normal structure of the neck during radiation therapy for pharyngeal cancer, and evaluated the necessity of an adaptive strategy. Ten patients with pharyngeal cancer who underwent radical chemoradiation therapy using 3-dimensional conformal radiation therapy RT (66-70 Gy in 33-35 fractions) between April 2009 and September 2010 were enrolled in the study. Patients underwent CT scans every week during their course of treatment. We analyzed the CT data in the radiation treatment planning system and measured changes of tumor, organ at risk, and neck volume. Gross tumor volume (GTV) was rapidly reduced by 28% of the original volume on average in the first 3 weeks. The right and left submandibular glands volume decreased to 70% and 63% of their initial volumes on average, respectively. The volume of the neck in the radiation fields decreased to 89% of its initial volume on average by the sixth week mainly caused by body weight loss due to acute radiation morbidity. Considerable anatomical change in the radiation filed that will affect dose distribution of the target and organ at risk was observed during radiation therapy for head and neck cancer.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
60
Issue
1-2
Start Page
46
End Page
51
Sort Key
46
Published Date
2013-02
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
Oral Sciences
University Hospital