ID 106046
Author
Nose, Ayumi Department of Radiology, Tokushima University Hospital
Otsuka, Hideki Department of Radiology, Tokushima University Hospital|Department of Medical Imaging, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nose, Hayato Department of Radiology, Tokushima University Hospital
Terazawa, Kaori Department of Radiology, Tokushima University Hospital
Keywords
201Tl-SPECT
brain tumors
retention index
differential diagnosis
Content Type
Journal Article
Description
Objective : To evaluate the usefulness of 201Tl-SPECT in differentiating benign from malignant brain tumors. Methods and Materials : Eighty-eight patients (44 males and 44 females) with 58 high-grade (WHO grade III-IV) and 30 low-grade (WHO grade III) tumors were evaluated with 201Tl-SPECT. (1) Visual assessment was performed by board-certificated radiologists using 201Tl-SPECT. Tumors were classified in two groups (Tl-positive and Tl-negative) and scored using the five grade evaluation system. Receiver operating characteristic (ROC) analysis was performed in the Tl-positive group. (2) Semi-quantitative assessment involved measurement of early and delayed 201Tl uptake, and the retention index (RI) was applied as follows : RI=delayed uptake ratio/early uptake ratio. Three combinations of RI using mean and maximum values of the region of interest were calculated. Results : (1) Seventy-four Tl-positive and 14 Tl-negative tumors. The area under the ROC curve (AUC) estimated by three radiologists exceeded a value of 0.7. The value was greater when estimated by the more experienced radiologist. (2) In all RIs, the difference of RI between high-grade tumors and low-grade tumors was statistically significant. Conclusion : A visual and semi-quantitative assessment using 201Tl-SPECT was found to be useful for differentiating benign from malignant brain tumors.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
60
Issue
1-2
Start Page
121
End Page
126
Sort Key
121
Published Date
2013-02
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital