ID 109521
Title Alternative
グルタミンは抗癌剤起因性腸炎モデルラットの小腸粘膜を保護する
Glutamine protects small intestinal mucosa
Author
Harada, Nagakatsu the University of Tokushima KAKEN Search Researchers
Asakura, Megumi the University of Tokushima
Minato, Takuya the University of Tokushima
Furukita, Yoshihito the University of Tokushima
Yamamoto, Yota the University of Tokushima KAKEN Search Researchers
Yuasa, Yasuhiro the University of Tokushima
Yamai, Hiromichi the University of Tokushima
Seike, Junichi the University of Tokushima
Keywords
glutamine
gastrointestinal toxity
anticancer drug
diamine oxidase
IgA
Content Type
Thesis or Dissertation
Description
Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO[○R]) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
61
Issue
1-2
Start Page
59
End Page
64
Sort Key
59
Published Date
2014-02
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201405131006.pdf
論文本文 : LID201405281003.pdf
本論文は,著者Hirokazu Takechiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2742号
Diploma Number
甲医第1203号
Granted Date
2014-03-19
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences
Bioscience and Bioindustry