ID 109521
Author
Takechi, Hirokazu Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Mawatari, Kazuaki Department of Preventive Environent and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Harada, Nagakatsu Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Nakaya, Yutaka Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Asakura, Megumi Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Aihara, Mutsumi Department of Preventive Environent and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Takizawa, Hiromitsu Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Goto, Masakazu Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nishino, Takeshi Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Minato, Takuya Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
Furukita, Yoshihito Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamamoto, Yota Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Yuasa, Yasuhiro Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamai, Hiromichi Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
Yoshida, Takahiro Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Seike, Junichi Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School
Tangoku, Akira Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
glutamine
gastrointestinal toxity
anticancer drug
diamine oxidase
IgA
Content Type
Journal Article
Description
Supportive therapy during chemotherapy has become essential, but effective
preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy
of glutamine in rat anticancer drug-induced enteritis model. In this study, we used
twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered
at 20mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber
and oligosaccharide (GFO[○R]) (1000 mg/kg/day) groups. All groups were sacrificed on day 6
and upper jejunums were excised. The jejunal villous height was measured in specimens.
IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured.
The jejunal villous height was recognized as shorter in the specimen from 5-FU
treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase
activity in 5-FU+glutamine group were significantly superior to that in 5-FU group
(p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine
group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity
and IgA level in jejunal washing solution showed no significant difference between
5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective
effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis
model.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
61
Issue
1-2
Start Page
59
End Page
64
Sort Key
59
Published Date
2014-02
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences
Bioscience and Bioindustry