ID 109545
Author
Ohnishi, Ritsuko Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
Segawa, Hiroko Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ohmoto, Tomoyo Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
Sasaki, Shohei Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
Hanazaki, Ai Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
Mori, Ayaka Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
Ikuta, Kayo Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
Furutani, Junya Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
Kawakami, Eri Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
Tatsumi, Sawako Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Hamada, Yasuhiro Department of Therapeutic Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Miyamoto, Ken-ichi Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
dietary phosphate
sensing
calcium
phosphate excretion
Content Type
Journal Article
Description
Dietary inorganic phosphate (Pi) is the most important factor in the regulation of renal Pi excretion. Recent studies suggest the presence of an enteric-renal signaling axis for dietary Pi as well as the existence of a mechanism by which the intestine detects changes in luminal Pi concentrations. The mechanisms of intestinal Pi sensing, however, are unknown. In the present study, we focused on Pi depletion signals and investigated the effects of dietary components on intestinal Pi sensing. After feeding rats experimental diets for 3 days, we investigated urinary Pi excretion and plasma biochemical parameters. Renal Pi excretion was suppressed in rats fed a low-Pi diet (0.02% Pi). Elimination of dietary calcium (Ca) completely blocked the suppression of Pi excretion, suggesting that the presence of Ca is essential for the Pi depletion signal. Furthermore, a minimum Ca content of more than 0.02% was necessary for the Pi depletion signal. Magnesium, lanthanum, and strontium, which are agonists of calcium sensing receptor, instead of Ca, reduced Pi excretion.Therefore, dietary Ca appears to be important for the Pi depletion-sensing mechanism in the gastrointestinal tract. In addition, the calcium sensing receptor may be involved in the Pi depletion signal.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
61
Issue
1-2
Start Page
162
End Page
170
Sort Key
162
Published Date
2014-02
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences