ID 109607
Title Transcription
カンセン チリョウ ニ アタラシイ ジダイ ノ マクアケ : セイブツガクテキ セイザイ
Title Alternative
The opening of a new age in the treatment of psoriasis : Biologics
Author
Ishigami, Takeshi Department of Dermatology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Kubo, Yoshiaki Department of Dermatology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
psoriasis
TNF-α
Interleukin12/23
biologics
Content Type
Journal Article
Description
Psoriasis is a chronic inflammatory skin disease, which is clinically characterized by scaly erythemas on the whole body. In the fully developed lesions of psoriasis, the histological features have demonstrated epidermal hyperproliferation with infiltration of T lymphocytes in the dermal papillae. Although pre-biological systemic therapies has targeted mainly proliferative keratinocytes and activated T cells, their effects were limited or these therapies could not be applied for patients with severe organ failures. Therefore, more effective agents are expected to improve quality of life (QOL) of patients with psoriasis. Recent studies have showed what kinds of cells, cell surface molecules, and cytokines should play a pivotal role in the pathogenesis of psoriasis. Biological therapies targeting these molecules have proved to be so effective for obstinate lesions of psoriasis. Here, we describe clinical features and pathogenesis of psoriasis, and the characteristics of several conventional and biological therapies for psoriasis in Japan.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
69
Issue
1-2
Start Page
3
End Page
6
Sort Key
3
Published Date
2013-04-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital