ID 109609
Title Transcription
イショセイ シボウ ト 2ガタ トウニョウビョウ シンゾウ ケッカンビョウ
Title Alternative
Ectopic fat deposition, type 2 diabetes mellitus and cardiovascular diseases
Author
Shimabukuro, Michio Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences|Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
Dagvasumberel, Munkhbaatar Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
Ishida, Masayoshi Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
Matsumoto, Sachiko Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
Kozuka, Chisayo Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
Taira, Shin-ichiro Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
Yabiku, Kouichi Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
Yagi, Shusuke Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Fukuda, Daiju Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences|Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yamada, Hirotsugu Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Soeki, Takeshi Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Wakatsuki, Tetsuzo Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Oyadomari, Seiichi Division of Molecular Biology, Institute for Genome Research, the University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Masuzaki, Hiroaki Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
Sata, Masataka Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Ectopic fat deposition
Diabetes mellitus
Cardiovascular diseases
Obesity
Metabolic syndrome
Lipotoxicity
Content Type
Journal Article
Description
There is evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as the metabolic syndrome (MetS). Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in the liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. In addition, ectopic fat deposition play a critical role in the heart components such as (1) circulatory and locally recruited fat, (2) intra-and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is discussed via possible mechanisms including adipocytokine, insulin resistance and lipotoxicity.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
69
Issue
1-2
Start Page
21
End Page
28
Sort Key
21
Published Date
2013-04-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital
Institute of Advanced Medical Sciences