ID 109635
Author
Li, Xu-Hui Tsinghua-Peking Center for Life Sciences, Tsinghua University|Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University
Wang, Elaine Lu Department of Legal Medicine, Kanazawa Medical University|Department of Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
Zhou, Hai-Meng Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University
Yoshimoto, Katsuhiko Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Qian, Zhi Rong Department of Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School|Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School|Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
Content Type
Journal Article
Description
MicroRNAs (miRNAs) are a class of recently identified noncoding RNAs that regulate gene expression at posttranscriptional level.
Due to the large number of genes regulated by miRNAs, miRNAs play important roles in many cellular processes. Emerging evidence indicates that miRNAs are dysregulated in pituitary adenomas, a class of intracranial neoplasms which account for 10–15% of diagnosed brain tumors. Deregulated miRNAs and their targets contribute to pituitary adenomas progression and are associated with cell cycle control, apoptosis, invasion, and pharmacological treatment of pituitary adenomas. To provide an overview of miRNAs dysregulation and functions of these miRNAs in pituitary adenoma progression, we summarize the deregulated miRNAs and their targets to shed more light on their potential as therapeutic targets and novel biomarkers.
Journal Title
International Journal of Endocrinology
ISSN
16878337
Volume
2014
Start Page
1
End Page
11
Sort Key
1
Published Date
2014
Remark
Copyright © 2014 Xu-Hui Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
EDB ID
Published Source
International Journal of Endocrinology Volume 2014, Article ID 435171, 11 pages http://dx.doi.org/10.1155/2014/435171
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences