Effects of Decreased Loading on the Mandible
Tanaka, Eiji Tokushima University|King Abdulaziz University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ruijven, Leo J. van University of Amsterdam and VU University Amsterdam
Langenbach, Geerling E. J. University of Amsterdam and VU University Amsterdam
Thesis or Dissertation
Bone mass and mineralization are largely influenced by loading. The purpose of this study was to evaluate the reaction of the entire mandibular bone in response to decreased load during growth. It is hypothesized that decreased muscular loading will lead to bone changes as seen during disuse, i.e. loss of bone mass.
Methods and Findings
Ten 21-day-old Wistar strain male rats were divided into two groups (each n=5) and fed on either a hard- or soft-diet for 11 weeks. Micro-computed tomography was used for the investigation of bone mineralization, bone volume, bone volume fraction (BV/TV) and morphological analysis. Mandibular mineralization patterns were very consistent, showing a lower degree of mineralization in the ramus than in the corpus. In the soft-diet group, mineralization below the molars was significantly increased (p<0.05) compared to the hard diet group. Also, bone volume and BV/TV of the condyle and the masseter attachment were decreased in the soft-diet group (p<0.05). Morphological analysis showed inhibited growth of the ramus in the soft-diet group (p<0.05).
Decreased loading by a soft diet causes significant changes in the mandible. However, these changes are very region-specific, probably depending on the alterations in the local loading regime. The results suggest that muscle activity during growth is very important for bone quality and morphology.
内容要旨 : LID201606141001.pdf
審査要旨 : LID201606141002.pdf
論文本文 : LID201606141003.pdf
本論文は, 著者Natsuko Hichijoの学位論文として提出され, 学位審査・授与の対象となっている。
Copyright: © 2015 Hichijo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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LID201606141001.pdf 142 KB
LID201606141002.pdf 407 KB
LID201606141003.pdf 3.15 MB
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Doctor of Dental Science