ID 109744
Title Transcription
カレイ オウハン ヘンセイ ニ タイスル サイセイ イリョウ
Title Alternative
Regeneration therapy for age-related macular degeneration
Author
Katome, Takashi Department of Ophthalmology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Age related macular degeneration
induced Pluripotent Stem
retinal pigment epithelial sheet
Content Type
Journal Article
Description
Age related macular degeneration (AMD) is one of major cause of blindness in developed country. A clinical trial using induced Pluripotent Stem (iPS)-derived retinal pigment epithelial (RPE) sheet transplantation for exudative AMD is now going to start. The basic aim of the RPE transplantation therapy is completely different from that of the current standard anti-vascular endothelial growth factor (VEGF) therapy in a sense that the former is the radical treatment whereas the latter is basically a symptomatic treatment with certain limitations. In anti-VEGF therapy, subfoveal scar tissue or scarred choroidal neovascular membrane may induce gradual vision decrease without exudative changes. The purpose of the current clinical trial is to confirm the safety of the use of iPS-derived RPEs. Pre-clinical researches using iPS-derived photoreceptors
for retinal degeneration are also under way.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
70
Issue
1-2
Start Page
3
End Page
6
Sort Key
3
Published Date
2014-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital