ID 109762
Title Transcription
シカ チリョウ ト カンセンセイ シンナイマクエン ノ ヨボウ
Title Alternative
Prevention of Dental Practice-Induced Infective Endocarditis
Author
Ito, Hiro-O Department of Preventive Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
感染性心内膜炎
歯科治療
口腔常在菌
ビリダンスレンサ球菌
コンビナトリアルライブラリー
分子模倣
Content Type
Journal Article
Description
Infective endocarditis is a serious infection of the endothelial surfaces of the heart, especially at the valves. Oral commensal bacteria are the most common etiologic agents of this disease. Infective endocarditis can be established when all the 3 conditions are present simultaneously, i.e., (1) the introduction of bacteria into the bloodstream, (2) predisposing impairments in the heart, and (3) the virulence of bacteria. Common dental procedures, even non-surgical dental procedures, can often cause bacteremia of oral commensals. Periodontally diseased patients are at risk from bacteremia even after brushing the teeth or eating meals. Bacteremia itself rarely affect healthy people but they can result in mortal infective endocarditis in those who have a predisposed risk for this disease, such as those with heart valve diseases, pacemaker implantation, etc. Despite advances in diagnosis, antimicrobial therapies, surgical techniques and management of complications, patients with infective endocarditis still have substantial mortality. To prevent this infection, antibiotics is currently used, however, their frequent uses generates drug-resistant mutant bacteria, which is a serious social problem. Therefore, development of novel alternative drugs to be used instead of the current antibiotics is highly desired. We are now using several types of combinatorial peptide libraries to search for small size molecular mimetics that can interfere with the adhesion of bacteria to the target tissue. The use of such peptides is expected to lead to the development of compounds for a novel preventive drug which does not kill bacteria, thus making it safer and less likely to generate drugresistant mutants.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
20
Issue
2
Start Page
191
End Page
198
Sort Key
191
Published Date
2008-01-31
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences