ID 109765
Title Transcription
コウクウ サイキン ノ ネツ ショック タンパクシツ ト ソノ シシュウビョウ エノ カンヨ
Title Alternative
Heat Shock Proteins from Oral Bacteria and Their Potential Contributions to Periodontal Disease
Author
Hinode, Daisuke Department of Fundamental Oral Health Science, School of Oral Health and Welfare, The University of Tokushima Faculty of Dentistry Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
口腔細菌
熱ショック蛋白質
歯周病
Content Type
Journal Article
Description
The oral cavity is subjected to a wide range of environmental changes such as heat stress that may affect the biology of oral bacteria. Bacterial heat shock proteins (HSPs), especially, GroEL protein is one of immunodoninant antigen in infection. The high degree of conservation of GroEL implies that molecular mimicry may occur, antibodies against microbial GroEL can cross-react with host HSP60 antigens. Several groups showed that GroEL proteins from periodontopathogenic bacteria were immunodoninant serum antigens in patients with periodontitis. It also revealed in our study the immunologic cross-reactivity between human fibronectin and Actinobacillus actinomycetmcomitans GroEL. These phenomena may lead to an autoimmune response and contribute to tissue destruction during periodontitis. On the other hand, Campylobacter rectus GroEL and A. actinomycetmcomitans GroEL possessed the ability to stimulate production of interleukin (IL)-6 by a confluent monolayer of human gingival epithelial cells and gingival fibroblasts. This result clearly indicates that GroEL proteins play a role in initiation and progression of periodontal disease. Interestingly, salivary IgA antibody directed to C. rectus GroEL from patients with priodontitis caused a partial inhibition of IL-6 production. Salivary IgA may have a protective role by reducing the inflammatory response induced by oral microbial GroEL. I review here the several reports regarding HSPs from oral bacteria and demonstrate their potential contributions to periodontal disease.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
20
Issue
2
Start Page
215
End Page
221
Sort Key
215
Published Date
2008-01-31
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences