ID 109768
Title Transcription
シシュウエン ニオケル ケモカイン ノ ハツゲン オヨビ ハツゲン セイギョ ニ カンスル ケンキュウ
Title Alternative
The study of Chemokines in Periodontal Diseases and Regulation of its Expression
Author
Hosokawa, Yoshitaka Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
歯周炎
ケモカイン
炎症性細胞
Content Type
Journal Article
Description
Periodontal disease, a chronic inflammatory disease of the attachment structures of the teeth, is one of the most significant causes of tooth loss in adults and the most prevalent form of bone pathology in humans, besides being a modifying factor of an individual's systemic health. The bacterial biofilm attached to the surface of the tooth, close to the periodontal tissues, is the etiologic factor for this disease. Inflammatory and immune responses, initiated by periodontopathogens, are thought to protect the host against infection; however, the persistence of a local chronic host response may alter the protective roles of inflammatory cells and produce deleterious effects in these tissues. In fact, the development of periodontal diseases seems to be related to the progression of the inflammatory cell infiltrate into the deeper periodontal tissues. In this situation, chemokines, found in both gingival tissue and crevicular fluid, are thought to play important roles in the immunopathogenesis of periodontal diseases. Recently, we have reported that an intense expression of chemokines, including fractalkine, CCL20 and CXCL16, in periodontal diseased tissues can be observed. In periodontal connective tissues, fractalkine can drive the migration of NK cells. CCL20 is a chemoattractant of memory-type T cells and immature dendritic cells, and CXCL16 can attract Th1-type lymphocytes and NKT cells. These chemokines might be involved in the initiation and progression of periodontal disease.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
20
Issue
2
Start Page
235
End Page
239
Sort Key
235
Published Date
2008-01-31
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences