ID 109779
Title Transcription
フクコウジョウセン キノウ コウシンショウ : ガク シュヨウ ショウコウグン ノ ゲンイン イデンシ サンブツ パラフィブロミン
Title Alternative
Parafibromin, Product of the Hyperparathyroidism : Jaw Tumor Syndrome Gene HRPT2
Author
Iwata, Takeo Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN Search Researchers
Keywords
パラフィブロミン
副甲状腺機能亢進症-顎腫瘍症候群(HPT-JT)
HRPT2
癌蛋白質
癌抑制蛋白質
Content Type
Journal Article
Description
Primary hyperparathyroidism is characterized by the calcium-insensitive hypersecretion of parathyroid hormone and formation of parathyroid tumors. The disease usually results from a single parathyroid adenoma, but in a minority of cases is a part of hereditary syndromes; multiple endocrine neoplasia types 1 and 2A, familial isolated hyperparathyroidism, and hyperparathyroidism-jaw tumor (HPT-JT) syndrome. HPT-JT syndrome is characterized by parathyroid tumors, fibro-osseous lesions of the mandible and maxilla, and renal cysts and tumors. The gene whose inactivation is directly associated with the pathogenesis of HPT-JT syndrome has been identified as the tumor suppressor gene HRPT2. Parafibromin, a 531-amino acid protein encoded by HRPT2, has partial homology with the yeast Cdc73, a component of the RNA polymerase II-associated Paf1 complex including Paf1, Leo1, Ctr9, and Rtf1. Parafibromin binds to RNA polymerase II as a part of human Paf1 complex together with human orthologs of Paf1, Leo1, Ctr9. Human Paf1 complex appears to be involved in transcription elongation. Parafibromin has antiproliferative activity by inhibition of cyclin D1 and c-myc proto-oncoprotein. Whereas, we recently demonstrated that parafibromin acts as a positive regulator of cell growth like an oncoprotein in the presence of SV40 large T antigen, indicating parafibroimin has potentially ambivalent functions in tumorigenesis. This review focuses on the functions of parafibromin and human Paf1 complex, providing an insight into its potential involvement in the development of cancer.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
21
Issue
2
Start Page
327
End Page
332
Sort Key
327
Published Date
2009-01-31
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences