ID 109802
Title Transcription
シェーグレン ショウコウグン ニ タイスル ビョウキ タイオウガタ テーラーメード イリョウ ノ コウチク
Title Alternative
Establishment of a Tailor-made Therapy Based on the Disease-stage of Sjögren's Syndrome
Author
Azuma, Masayuki Department of Oral Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
唾液腺
口腔乾燥症
腺房細胞
導管細胞
Content Type
Journal Article
Description
Sjögren's syndrome (SS) is one of the most common rheumatic diseases. Histopathologic features of SS salivary glands include: (a) the eventual total replacement of the acinar structure by marked lymphocytic infiltrate and (b) the occurrence of various changes in the ductal structure within infiltrated areas, such as metaplasia, hyperplasia, thinning of ductal layer, or oncocytic change, and in some cases the formation of epimyoepithelial islands arising from ductal proliferation. Accordingly, surviving and/or proliferating ductal cells in SS salivary glands may be regarded as one of the possible sources for the improvement of salivary secretion. Thus far, I found that inhibition of TNF-α-induced MMP-9 production in acinar cells lead to restored integrity of the acinar structure in SS salivary glands. Therefore, in this review I would like to postulate a tailor-made therapy based on the diseasestage of SS. First, therapy for the inhibition of lymphocytic infiltrate into salivary glands by regulating balance of sex hormones in acinar cells (early stage of SS); second, therapy for the maintenance of stable acinar structure by inhibiting cytokine-induced basement membrane-degrading enzymes, such as MMP-9 (intermediate stage of SS); and third, therapy for the bestowal of ability to secrete saliva on ductal cells (late stage of SS). Hopefully, these disease stage-specific therapies would contribute to the improvement of QOL of SS patients.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
23
Issue
2
Start Page
85
End Page
89
Sort Key
85
Published Date
2011-01-31
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences