ID 109824
Title Transcription
ジコ メンエキ シッカン ノ ビョウタイ カイメイ ニ ムケタ タカクテキ ケンキュウ
Title Alternative
Multilateral Study for Defining Pathogenesis of Autoimmunity
Author
Ishimaru, Naozumi Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
自己免疫疾患
シェーグレン症候群
T細胞
Content Type
Journal Article
Description
Immune cells normally attack exogenous bacteria or viruses without harming the body's cells or tissues. However, any abnormality in these immune cells could consequently result in cell or tissue damage of various organs, including the pancreas, salivary glands, and joints as the targets of autoimmune diseases. Autoimmune diseases result from complex and multigenic phenotypes that affect by a variety of genetic and environmental or stochastic factors. Fundamental treatments for autoimmune diseases have not yet been established. In this review, we introduce the following: (1) useful animal models for Sjögren's syndrome (SS), (2) the critical role of estrogen in autoimmunity, (3) the influence of environmental hormones on autoimmunity, (4) the cell signaling in autoimmunity, and (5) the therapeutic strategy for autoimmune disease.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
25
Issue
2
Start Page
15
End Page
19
Sort Key
15
Published Date
2013-01-31
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences