ID 109825
Title Transcription
チュウスウ シンケイケイ NMDA ジュヨウタイ ノ カツドウ ガ ヒキオコス ケイケン イゾンテキ シナプス カソセイ ノ セイリガクテキ オヨビ ビョウタイ セイリガクテキ ヨウソウ
Title Alternative
Physiological and Pathophysiological Conditions of Experience-dependent Synapse Plasticity Induced by NMDA Receptor Activation in the Central Nervous Systems
Author
Yoshimura, Hiroshi Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
シナプス可塑性
NMDA受容体
Mg2+ブロック
Hebbの学習則
慢性疼痛
Content Type
Journal Article
Description
N-methyl-D-aspartate (NMDA) receptors play an important role in neural plasticity in the central nervous systems (CNSs). We can change our behaviors according to storing things in memory and learning, and the ability is necessary for survival in the daily life. The “learning and memory” is based on experience-dependent neural plasticity in the CNSs. NMDA receptor activation is essential for inducing plastic changes in the structural and functional refinement of synapses and circuits. “Hebbian learning” is an important form of learning and memory. Mg2+ block is a fine equipment of NMDA receptor, and is required to establish“ Hebbian learning”. NMDA receptor activation, however, does not always induce preferred conditions. There are cases that, in particular situations, NMDA receptor activation-dependent plasticity causes pathological conditions. In this review, I will overview the roles of the NMDA receptors in physiological and pathophysiological conditions.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
25
Issue
2
Start Page
21
End Page
27
Sort Key
21
Published Date
2013-01-31
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences