ID 109849
Title Transcription
RNA カンショウホウ オ モチイタ キン イシュクセイ シッカン ニ タイスル カクサン イヤク ノ カイハツ ケンキュウ
Title Alternative
Development Study of the Nucleic Acid Innovative Drug for the Muscular Atrophy-related Disease using the RNA Interference Method
Author
Kinouchi, Nao Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN Search Researchers
Keywords
マイオスタチン
RNA 干渉法 (RNA interference : RNAi)
short interference RNA (siRNA)
筋芽細胞
骨格筋
Content Type
Journal Article
Description
Skeletal muscle is one of the most important morpho-functional organs, and its atrophy causes severe conditions such as muscular dystrophies. RNA interference (RNAi)-based gene therapy has been expected as a safe remedy without side effects. However, the rapid degradation of small interfering RNAs (siRNAs) and their limited duration of activity require efficient delivery methods.
Atelocollagen (ATCOL)- or cationic liposome-mediated administration of siRNAs is a promising approach to disease treatment, including muscular atrophy. In thie study, we used RNAi to control the expression of myostatin, a negative regulator of skeletal muscle formation, for the purpose of developing a good as new method to regulate skeletal muscle volume, and report herein that ATCOL- or cationic liposome-mediated administration of a myostatin-targeting siRNA into skeletal muscles of normal and diseased mice induced a marked increase in muscle mass and a recovery of myofunction. We are now trying to examine the effectiveness of systemic administration of cationic liposome-delivered myostatin-targeting siRNA. Since cationic liposomes delivered siRNA to muscles effectively and are safe and cost-effective, they may represent a powerful therapeutic tool for disease treatment, including muscular atrophy.
In this review, I would like to summarize about possibility to regulate skeletal muscle volume and to develop a new treatment for various muscle disorders by RNAi technique.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
27
Issue
1
Start Page
1
End Page
9
Sort Key
1
Published Date
2014-06-30
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital