ID 109891
Title Transcription
ケッカン シンセイ ソガイ チリョウ ニヨッテ カッセイカ スル アクセイ シュヨウカ ノンコーディング RNA ノ カイメイ
Title Alternative
Long non-coding RNAs : new players in cancer biology
Author
Teshima-Kondo, Shigetada Department of Nutritional Physiology, Institute of Health Biosciences, Tokushima University Graduate School KAKEN Search Researchers
Keywords
non-coding RNA
cancer
lncRNA
lincRNA
Content Type
Journal Article
Description
The most well-studied sequences in the human genome are those of protein-coding genes. However, the coding exons of these genes account for only1.5% of the genome. In recent years, FANTOM and ENCODE projects reveal that more than 80% of the human genome is transcribed into RNAs that do not encode protein. It has become increasingly apparent that the non-protein-coding RNAs (ncRNAs) are of crucial functional importance : for normal development and physiology, and for disease. In particularly cancer, it is increasing evidence that not only miRNAs but also other ncRNAs, such as large intergenic non-coding RNAs (lincRNAs) and long non-coding RNAs (lncRNAs), function as oncogenic ncRNAs and tumor-suppressive ncRNAs.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
70
Issue
5-6
Start Page
121
End Page
126
Sort Key
121
Published Date
2014-12-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences