ID 109893
Title Transcription
ヒト ノ ケンコウ ホジ ニオケル チョウナイキン ノ ヤクワリ
Title Alternative
Intestinal microbiota and its role in human health
Author
Kataoka, Keiko Department of Microbiology and genetic analysis, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
intestinal microbiota
ulcerative colitis
prebiotics
Bacteroides
organic acid
Content Type
Journal Article
Description
The healthy gut environment is complicated and controlled by the balance of intestinal immune system, intestinal microbiota, and microbial metabolites produced by intestinal bacteria. Imbalance of these elements in genetically susceptible persons has been known to promote inflammatory bowel disease and some lifestyle-related illnesses. Manipulation of intestinal microbiota with prebiotics, which can selectively stimulate a growth of beneficial bacteria, might contribute to keep healthy condition and to improve patient’s condition. I present some results of prebiotic effects in animal model and placebo-controlled, crossover study in healthy adults and patients with ulcerative colitis (UC). Through the clinical study, we found that UC patients had differences in microbiota composition and microbial metabolites. Decrease of Dominant anaerobic bacteria Bacteroides and diversity of microbiota composition was observed in UC. Amount of organic acids produced by bacterial fermentation reflectively decreased. Update on correlation of intestinal bacteria with human health and disease are reviewed.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
70
Issue
5-6
Start Page
139
End Page
148
Sort Key
139
Published Date
2014-12-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences