ID 109903
Title Transcription
Trastuzumab タンザイ リョウホウ ガ チョコウ シタ セツジョ フノウ シンコウ イガン ノ 1レイ
Title Alternative
A case of a positive response to trastuzumab in a patient with HER2-overexpressing metastatic gastric cancer
Author
Miyauchi, Masahiro The Post-graduate Education Center, Tokushima University Hospital
Teramae, Satoshi Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Miyamoto,  Hiroshi Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Otsuka,  Kanako Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Miyoshi, Jinsei Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Kagawa, Miwako Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Takaba, Azusa Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Taniguchi, Tatsuya Department of Gastroenterology and Oncology, the University of Tokushima Graduate School KAKEN Search Researchers
Goji, Takahiro Department of Gastroenterology and Oncology, the University of Tokushima Graduate School KAKEN Search Researchers
Kitamura, Shinji Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Takaoka, Tohshi Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Niki, Miyako Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Sato, Momoko Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Muguruma, Naoki Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Okahisa, Toshiya Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Imoto, Issei Department of Human Genetics and Public Health, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sawa, Yasuhiko Sawa Clinic
Takayama, Tetsuji Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Trastuzumab
HER2
gastric cancer
docetaxel
S‐1
Content Type
Journal Article
Description
Trastuzumab, a humanized monoclonal antibody directed against human epidermal growth factor receptor2 (HER2), has been shown to be active against metastatic gastric cancer that overexpress HER2. A 78-year-old man presented with an edema in the lower legs. He was diagnosed as having advanced gastric cancers with multiple liver metastases in our hospital. Immunohistochemistry of the tumor cells revealed HER2 overexpression with an intensity of 3+. The patient was treated with DS-T chemotherapy (Docetaxel+S‐1+Trastuzumab) because of the presence of renal dysfunction. Due to the adverse effect appeared with his skin, DS-T chemotherapy has been canceled and trastuzumab chemotherapy was continued. After 11 months of trastuzumab monotherapy, metastatic liver tumors were diminished. There is very few report of a positive response to trastuzumab in a patient with HER2‐overexpressing metastatic gastric cancer.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
70
Issue
5-6
Start Page
185
End Page
190
Sort Key
185
Published Date
2014-12-25
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Medical Sciences