ID 109917
Title Transcription
Trastuzumab/Capecitabine/Cisplatin HXP リョウホウ ニヨル 2ジ チリョウ ガ ユウコウ デアッタ シンコウ イガン ノ 1レイ
Title Alternative
A case of the advanced gastric cancer of which second line chemotherapy using Trastuzumab/Capecitabine/Cisplatin therapy was effective
Author
Yuasa, Yasuhiro Department of Digestive Surgery, Tokushima Red Cross Hospital
Okitsu, Hiroshi Department of Digestive Surgery, Tokushima Red Cross Hospital
Goto, Masakazu Department of Digestive Surgery, Tokushima Red Cross Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Edagawa, Hiroshi Department of Digestive Surgery, Tokushima Red Cross Hospital
Mori, Osamu Department of Digestive Surgery, Tokushima Red Cross Hospital
Tani, Ryotaro Department of Digestive Surgery, Tokushima Red Cross Hospital
Kuramoto, Shunsuke Department of Digestive Surgery, Tokushima Red Cross Hospital
Matsumoto, Daisuke Department of Digestive Surgery, Tokushima Red Cross Hospital
Tomibayashi, Atsushi Department of Digestive Surgery, Tokushima Red Cross Hospital
Keywords
gastric cancer
second line chemotherapy
Trastuzumab
Content Type
Journal Article
Description
The case was a 69-year-old man, and gastric cancer (papillary adenocarcinoma) was diagnosed by a close inspection of the abdominal pain in 2008, and it was our department introduction. Show the type 0‐IIa+IIc like advanced lesion of gastric middle body gastrointestinal endoscope, and CT showed no regional lymph node and distant metastases, and we diagnosed it as c-T2 (MP), N0, M0, stageIB. We performed laparoscopic distal gastrectomy with D2 dissection, and in pathology, acknowledgment of severe lymph node metastases was obtained, and diagnosed it as T3 (SE), N2, M0, stageIIIB. We gave adjuvant chemotherapy with S-1and Cisplatin for 5 cycles, and maintenance S-1alone up to 24 months after surgery.
There was no recurrence for 39 months after surgery. But multiple metastases to lung recurrence was acknowledged and we performed S-1/Docetaxel therapy for 6 cycles, which lead to progressive disease. Then we performed Trastuzumab/Capecitabine/Cisplatin chemotherapy (HXP), the anti-tumor effect was good, and after 14 months later, showed a liver metastasis, but the tolerability was good. Generally, it is said that the chemotherapy is poor at an effect after the second line treatment, but HXP may be useful even in the second line chemotherapy.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
71
Issue
1-2
Start Page
29
End Page
34
Sort Key
29
Published Date
2015-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences