ID 109924
Title Transcription
ドウジキ ニ 1ガタ トウニョウビョウ オ ハッショウシ タセンセイ ジコ メンエキ ショウコウグン IIIガタ ト シンダンシ エタ コウキ コウレイシャ ノ ドウホウ ショウレイ
Title Alternative
Late elderly siblings who simultaneously developed type 1 diabetes and were diagnosed with autoimmune polyglandular syndrome type III
Author
Morimoto, Jun The Medical Education Center, Tokushima Prefectural Central Hospital|Department of Diabetology and Metabolic Medicine, Tokushima Prefectural Central Hospital
Yamaguchi, Hiroshi Department of Diabetology and Metabolic Medicine, Tokushima Prefectural Central Hospital
Shirakami, Atsuhisa Department of Diabetology and Metabolic Medicine, Tokushima Prefectural Central Hospital
Omoya, Toshihiro Department of Gastroenterology, Tokushima Prefectural Central Hospital
Sekimoto, Etsuko Department of Hematology, Tokushima Prefectural Central Hospital
Otsuka, Satoshi Department of Internal Medicine, Tokushima Teisin Hospital
Fukuya, Akira Department of Gastroenterology, Oe Kyodo Hospital
Keywords
acute-onset autoimmune type 1 diabetes mellitus
polyglandular autoimmune syndrome type III
late elderly
brother and sister
Content Type
Journal Article
Description
We herein presented a case of a 79-year-old woman who was referred to our hospital with dry mouth and polyuria that had persisted for three months prior to her admission. She developed Hashimoto disease at 73 years old and pernicious anemia at 78 years old. Her blood glucose level was 682 mg/dl, HbA1c 14.6%, and urinary ketone was positive ; therefore, she was diagnosed with diabetic ketosis. Acute-onset autoimmune type 1 diabetes mellitus was diagnosed based on the diagnostic criteria for acute-onset type 1 diabetes mellitus (2012) by the committee of the Japan Diabetes Society. Autoimmune polyglandular syndrome was subsequently diagnosed based on the complications of type 1 diabetes and Hashimoto’s thyroiditis. Her 87-year-old brother had developed acute-onset autoimmune type 1 diabetes 2 months before his sister was hospitalized. Autoimmune polyglandular syndrome type III was also diagnosed because he had autoimmune thyroid disease. No epidemiological data are currently available for late elderly with acute-onset type 1 diabetes in Japan. To the best of our knowledge, this is the first case of acute-onset autoimmune type 1 diabetes mellitus that developed around the same time period in an elderly brother and sister who were diagnosed with autoimmune polyglandular syndrome type III. Common genetic and environmental factors were etiologically implicated in the almost simultaneous onset between these siblings.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
71
Issue
3-4
Start Page
87
End Page
94
Sort Key
87
Published Date
2015-08-25
FullText File
language
jpn
TextVersion
Publisher