ID 109934
Title Transcription
メタボリック シンドローム カンレン カンシッカン モデル ドウブツ ノ カイハツ ト オウヨウ : ヒト ビョウタイ カイセキ エノ シッカン ビョウリガクテキ アプローチ
Title Alternative
New animal models for the translational study of metabolic syndrome-associated liver diseases
Author
Tsuneyama, Koichi Department of Pathology and Laboratory Medicine, Tokushima University Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
animal model
metabolic syndrome
nonalcoholic steatohepatitis
hepatocellular carcinoma
Content Type
Journal Article
Description
Metabolic syndrome (MS) is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases that affect the entire body. The hepatic manifestations of MS include nonalcoholic fatty liver disease (NAFLD) and its progressive variant nonalcoholic steatohepatitis (NASH). NASH is known to extend into liver cirrhosis and hepatocellular carcinoma (HCC). To determine the pathogenesis and effective treatment, an excellent animal model of NASH/HCC is required. We recently succeeded to develop two MS associated NASH mice model (TSOD mice and DIAR-MSG mice). Their clinical course and pathological characters were quite similar to those of human MS-NASH patients. Interestingly, most of them developed HCC in aged,
which pathological and functional characters were identical to those of human HCC. In addition, we established a novel mouse model of HCC based on type 1 diabetes (DIAR-nSTZ mice) and reported its histopathological features. To compare these mice models from various aspects, we can highlight specific and useful characters of MS associated liver diseases including hepatocarcinogenesis.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
71
Issue
5-6
Start Page
113
End Page
120
Sort Key
113
Published Date
2015-12-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences